| Rio Grande City to St. Simons (Georgia) | 1,105.22 mi (1,778.67 km) |
| Rio Grande City to Stafford (Texas) | 299.57 mi (482.11 km) |
| Rio Grande City to Stallings (North Carolina) | 1,232.71 mi (1,983.86 km) |
| Rio Grande City to Stamford (Connecticut) | 1,761.72 mi (2,835.21 km) |
| Rio Grande City to Stanford (California) | 1,561.28 mi (2,512.64 km) |
| Rio Grande City to Stanton (California) | 1,252.85 mi (2,016.27 km) |
| Rio Grande City to Star (Idaho) | 1,552.40 mi (2,498.34 km) |
| Rio Grande City to Starkville (Mississippi) | 772.13 mi (1,242.63 km) |
| Rio Grande City to State College (Pennsylvania) | 1,557.08 mi (2,505.89 km) |
| Rio Grande City to Staten Island (New York) | 1,717.78 mi (2,764.49 km) |
| Rio Grande City to Statesboro (Georgia) | 1,106.36 mi (1,780.51 km) |
| Rio Grande City to Statesville (North Carolina) | 1,241.99 mi (1,998.80 km) |
| Rio Grande City to Staunton (Virginia) | 1,407.43 mi (2,265.04 km) |
| Rio Grande City to Steamboat Springs (Colorado) | 1,076.59 mi (1,732.60 km) |
| Rio Grande City to Steiner Ranch (Texas) | 281.00 mi (452.22 km) |
