| Rio Grande City to St. George (Utah) | 1,136.64 mi (1,829.25 km) |
| Rio Grande City to St. Helens (Oregon) | 1,884.14 mi (3,032.24 km) |
| Rio Grande City to St. James (New York) | 1,773.51 mi (2,854.19 km) |
| Rio Grande City to St. John (Indiana) | 1,224.96 mi (1,971.38 km) |
| Rio Grande City to St. Joseph (Missouri) | 952.68 mi (1,533.19 km) |
| Rio Grande City to St. Louis (Missouri) | 982.06 mi (1,580.48 km) |
| Rio Grande City to St. Louis Park (Minnesota) | 1,318.18 mi (2,121.40 km) |
| Rio Grande City to St. Marys (Georgia) | 1,088.16 mi (1,751.22 km) |
| Rio Grande City to St. Marys (Pennsylvania) | 1,554.09 mi (2,501.06 km) |
| Rio Grande City to St. Matthews (Kentucky) | 1,122.34 mi (1,806.23 km) |
| Rio Grande City to St. Michael (Minnesota) | 1,331.05 mi (2,142.12 km) |
| Rio Grande City to St. Paul (Minnesota) | 1,321.51 mi (2,126.77 km) |
| Rio Grande City to St. Peter (Minnesota) | 1,269.35 mi (2,042.82 km) |
| Rio Grande City to St. Peters (Missouri) | 980.25 mi (1,577.57 km) |
| Rio Grande City to St. Petersburg (Florida) | 997.90 mi (1,605.97 km) |
