| Rio Grande City to Southern Pines (North Carolina) | 1,300.12 mi (2,092.34 km) |
| Rio Grande City to Southfield (Michigan) | 1,417.45 mi (2,281.16 km) |
| Rio Grande City to Southgate (Michigan) | 1,405.78 mi (2,262.38 km) |
| Rio Grande City to Southlake (Texas) | 465.12 mi (748.55 km) |
| Rio Grande City to Spanaway (Washington) | 1,922.97 mi (3,094.72 km) |
| Rio Grande City to Spanish Fork (Utah) | 1,200.76 mi (1,932.44 km) |
| Rio Grande City to Spanish Lake (Missouri) | 992.01 mi (1,596.48 km) |
| Rio Grande City to Spanish Springs (Nevada) | 1,510.14 mi (2,430.33 km) |
| Rio Grande City to Sparks (Nevada) | 1,509.31 mi (2,429.01 km) |
| Rio Grande City to Spartanburg (South Carolina) | 1,163.07 mi (1,871.78 km) |
| Rio Grande City to Spearfish (South Dakota) | 1,281.82 mi (2,062.90 km) |
| Rio Grande City to Speedway (Indiana) | 1,175.79 mi (1,892.25 km) |
| Rio Grande City to Spencer (Iowa) | 1,176.66 mi (1,893.64 km) |
| Rio Grande City to Spokane (Washington) | 1,783.43 mi (2,870.16 km) |
| Rio Grande City to Spokane Valley (Washington) | 1,777.16 mi (2,860.06 km) |
