| Rio Grande City to South Plainfield (New Jersey) | 1,705.13 mi (2,744.14 km) |
| Rio Grande City to South Portland (Maine) | 1,990.20 mi (3,202.92 km) |
| Rio Grande City to South Riding (Virginia) | 1,505.82 mi (2,423.38 km) |
| Rio Grande City to South River (New Jersey) | 1,702.74 mi (2,740.29 km) |
| Rio Grande City to South Salt Lake (Utah) | 1,240.61 mi (1,996.56 km) |
| Rio Grande City to South San Francisco (California) | 1,580.10 mi (2,542.93 km) |
| Rio Grande City to South San Jose Hills (California) | 1,252.89 mi (2,016.33 km) |
| Rio Grande City to South Sioux City (Nebraska) | 1,119.47 mi (1,801.61 km) |
| Rio Grande City to South St. Paul (Minnesota) | 1,318.36 mi (2,121.70 km) |
| Rio Grande City to South Valley (New Mexico) | 756.69 mi (1,217.78 km) |
| Rio Grande City to South Venice (Florida) | 1,012.89 mi (1,630.09 km) |
| Rio Grande City to South Whittier (California) | 1,257.92 mi (2,024.43 km) |
| Rio Grande City to South Yarmouth (Massachusetts) | 1,935.53 mi (3,114.93 km) |
| Rio Grande City to Southaven (Mississippi) | 790.99 mi (1,272.97 km) |
| Rio Grande City to Southchase (Florida) | 1,077.37 mi (1,733.86 km) |
