| Rio Grande City to Shoreview (Minnesota) | 1,330.16 mi (2,140.69 km) |
| Rio Grande City to Shorewood (Illinois) | 1,207.42 mi (1,943.16 km) |
| Rio Grande City to Shorewood (Wisconsin) | 1,308.24 mi (2,105.40 km) |
| Rio Grande City to Short Hills (New Jersey) | 1,714.45 mi (2,759.13 km) |
| Rio Grande City to Short Pump (Virginia) | 1,460.69 mi (2,350.75 km) |
| Rio Grande City to Show Low (Arizona) | 861.77 mi (1,386.88 km) |
| Rio Grande City to Shreveport (Louisiana) | 517.73 mi (833.20 km) |
| Rio Grande City to Sicklerville (New Jersey) | 1,651.80 mi (2,658.32 km) |
| Rio Grande City to Sidney (Ohio) | 1,276.64 mi (2,054.56 km) |
| Rio Grande City to Sierra Madre (California) | 1,264.43 mi (2,034.90 km) |
| Rio Grande City to Sierra Vista (Arizona) | 780.95 mi (1,256.82 km) |
| Rio Grande City to Sierra Vista Southeast (Arizona) | 772.48 mi (1,243.19 km) |
| Rio Grande City to Signal Hill (California) | 1,262.39 mi (2,031.63 km) |
| Rio Grande City to Sikeston (Missouri) | 905.49 mi (1,457.24 km) |
| Rio Grande City to Siloam Springs (Arkansas) | 722.95 mi (1,163.47 km) |
