| Rio Grande City to Shelton (Connecticut) | 1,787.53 mi (2,876.75 km) |
| Rio Grande City to Shelton (Washington) | 1,953.28 mi (3,143.50 km) |
| Rio Grande City to Shenandoah (Louisiana) | 550.31 mi (885.63 km) |
| Rio Grande City to Shepherdsville (Kentucky) | 1,107.25 mi (1,781.95 km) |
| Rio Grande City to Sheridan (Wyoming) | 1,350.39 mi (2,173.24 km) |
| Rio Grande City to Sherman (Texas) | 517.65 mi (833.07 km) |
| Rio Grande City to Sherrelwood (Colorado) | 995.59 mi (1,602.25 km) |
| Rio Grande City to Sherwood (Arkansas) | 704.79 mi (1,134.26 km) |
| Rio Grande City to Sherwood (Oregon) | 1,864.50 mi (3,000.62 km) |
| Rio Grande City to Shiloh (Illinois) | 987.14 mi (1,588.65 km) |
| Rio Grande City to Shiloh (Ohio) | 1,251.49 mi (2,014.08 km) |
| Rio Grande City to Shiloh (Pennsylvania) | 1,575.27 mi (2,535.15 km) |
| Rio Grande City to Shirley (New York) | 1,784.02 mi (2,871.11 km) |
| Rio Grande City to Shively (Kentucky) | 1,112.92 mi (1,791.07 km) |
| Rio Grande City to Shoreline (Washington) | 1,949.55 mi (3,137.49 km) |
