| Rio Grande City to Seymour (Tennessee) | 1,103.80 mi (1,776.39 km) |
| Rio Grande City to Shady Hills (Florida) | 1,007.33 mi (1,621.14 km) |
| Rio Grande City to Shafter (California) | 1,357.82 mi (2,185.19 km) |
| Rio Grande City to Shaker Heights (Ohio) | 1,432.58 mi (2,305.52 km) |
| Rio Grande City to Shakopee (Minnesota) | 1,305.12 mi (2,100.39 km) |
| Rio Grande City to Sharon (Pennsylvania) | 1,463.58 mi (2,355.41 km) |
| Rio Grande City to Sharonville (Ohio) | 1,219.50 mi (1,962.60 km) |
| Rio Grande City to Shasta Lake (California) | 1,669.26 mi (2,686.42 km) |
| Rio Grande City to Shawnee (Kansas) | 903.37 mi (1,453.84 km) |
| Rio Grande City to Shawnee (Oklahoma) | 629.59 mi (1,013.23 km) |
| Rio Grande City to Sheboygan (Wisconsin) | 1,350.59 mi (2,173.57 km) |
| Rio Grande City to Shelby (North Carolina) | 1,192.89 mi (1,919.76 km) |
| Rio Grande City to Shelbyville (Indiana) | 1,179.55 mi (1,898.30 km) |
| Rio Grande City to Shelbyville (Kentucky) | 1,136.70 mi (1,829.34 km) |
| Rio Grande City to Shelbyville (Tennessee) | 965.06 mi (1,553.11 km) |
