| Rio Grande City to Security-Widefield (Colorado) | 920.30 mi (1,481.08 km) |
| Rio Grande City to Sedalia (Missouri) | 911.14 mi (1,466.33 km) |
| Rio Grande City to Sedro-Woolley (Washington) | 1,980.27 mi (3,186.94 km) |
| Rio Grande City to Seguin (Texas) | 227.71 mi (366.46 km) |
| Rio Grande City to Selden (New York) | 1,778.31 mi (2,861.92 km) |
| Rio Grande City to Selma (Alabama) | 822.24 mi (1,323.27 km) |
| Rio Grande City to Selma (California) | 1,408.56 mi (2,266.86 km) |
| Rio Grande City to Selma (Texas) | 223.66 mi (359.94 km) |
| Rio Grande City to Seminole (Florida) | 990.77 mi (1,594.49 km) |
| Rio Grande City to Seven Hills (Ohio) | 1,423.47 mi (2,290.85 km) |
| Rio Grande City to Seven Oaks (South Carolina) | 1,178.59 mi (1,896.75 km) |
| Rio Grande City to Severn (Maryland) | 1,551.78 mi (2,497.34 km) |
| Rio Grande City to Severna Park (Maryland) | 1,556.23 mi (2,504.51 km) |
| Rio Grande City to Sevierville (Tennessee) | 1,113.57 mi (1,792.12 km) |
| Rio Grande City to Seymour (Indiana) | 1,146.21 mi (1,844.65 km) |
