| Rio Grande City to Scottsboro (Alabama) | 949.37 mi (1,527.87 km) |
| Rio Grande City to Scottsdale (Arizona) | 928.05 mi (1,493.55 km) |
| Rio Grande City to Scranton (Pennsylvania) | 1,676.28 mi (2,697.71 km) |
| Rio Grande City to Seabrook (Maryland) | 1,539.42 mi (2,477.46 km) |
| Rio Grande City to Seabrook (Texas) | 319.98 mi (514.96 km) |
| Rio Grande City to Seaford (New York) | 1,751.17 mi (2,818.24 km) |
| Rio Grande City to Seagoville (Texas) | 454.42 mi (731.31 km) |
| Rio Grande City to Seal Beach (California) | 1,256.05 mi (2,021.42 km) |
| Rio Grande City to Searcy (Arkansas) | 742.21 mi (1,194.47 km) |
| Rio Grande City to Seaside (California) | 1,522.87 mi (2,450.82 km) |
| Rio Grande City to SeaTac (Washington) | 1,933.94 mi (3,112.38 km) |
| Rio Grande City to Seattle (Washington) | 1,942.80 mi (3,126.63 km) |
| Rio Grande City to Sebastian (Florida) | 1,131.31 mi (1,820.67 km) |
| Rio Grande City to Sebring (Florida) | 1,071.73 mi (1,724.78 km) |
| Rio Grande City to Secaucus (New Jersey) | 1,727.94 mi (2,780.85 km) |
