| Rio Grande City to Savannah (Georgia) | 1,131.42 mi (1,820.84 km) |
| Rio Grande City to Sayreville (New Jersey) | 1,705.92 mi (2,745.42 km) |
| Rio Grande City to Sayville (New York) | 1,772.79 mi (2,853.04 km) |
| Rio Grande City to Scaggsville (Maryland) | 1,543.06 mi (2,483.31 km) |
| Rio Grande City to Scarsdale (New York) | 1,747.98 mi (2,813.10 km) |
| Rio Grande City to Schaumburg (Illinois) | 1,240.86 mi (1,996.98 km) |
| Rio Grande City to Schenectady (New York) | 1,802.35 mi (2,900.61 km) |
| Rio Grande City to Schererville (Indiana) | 1,228.16 mi (1,976.53 km) |
| Rio Grande City to Schertz (Texas) | 222.72 mi (358.43 km) |
| Rio Grande City to Schiller Park (Illinois) | 1,242.70 mi (1,999.94 km) |
| Rio Grande City to Schofield Barracks (Hawaii) | 3,724.50 mi (5,994.01 km) |
| Rio Grande City to Scotchtown (New York) | 1,736.96 mi (2,795.36 km) |
| Rio Grande City to Scottdale (Georgia) | 1,008.34 mi (1,622.77 km) |
| Rio Grande City to Scotts Valley (California) | 1,543.71 mi (2,484.36 km) |
| Rio Grande City to Scottsbluff (Nebraska) | 1,104.81 mi (1,778.02 km) |
