| Rio Grande City to Santa Rosa (California) | 1,616.11 mi (2,600.88 km) |
| Rio Grande City to Santaquin (Utah) | 1,199.06 mi (1,929.69 km) |
| Rio Grande City to Santee (California) | 1,177.06 mi (1,894.29 km) |
| Rio Grande City to Sapulpa (Oklahoma) | 684.32 mi (1,101.31 km) |
| Rio Grande City to Saraland (Alabama) | 719.33 mi (1,157.66 km) |
| Rio Grande City to Sarasota (Florida) | 1,004.85 mi (1,617.15 km) |
| Rio Grande City to Sarasota Springs (Florida) | 1,009.06 mi (1,623.93 km) |
| Rio Grande City to Saratoga (California) | 1,549.98 mi (2,494.46 km) |
| Rio Grande City to Saratoga Springs (New York) | 1,818.30 mi (2,926.27 km) |
| Rio Grande City to Saratoga Springs (Utah) | 1,222.52 mi (1,967.46 km) |
| Rio Grande City to Sartell (Minnesota) | 1,353.27 mi (2,177.87 km) |
| Rio Grande City to Satellite Beach (Florida) | 1,124.64 mi (1,809.94 km) |
| Rio Grande City to Sauk Rapids (Minnesota) | 1,352.57 mi (2,176.75 km) |
| Rio Grande City to Sault Ste. Marie (Michigan) | 1,598.52 mi (2,572.58 km) |
| Rio Grande City to Savage (Minnesota) | 1,305.24 mi (2,100.58 km) |
