| Rio Grande City to Sanford (Maine) | 1,962.82 mi (3,158.86 km) |
| Rio Grande City to Sanford (North Carolina) | 1,319.80 mi (2,124.02 km) |
| Rio Grande City to Sanger (California) | 1,409.31 mi (2,268.07 km) |
| Rio Grande City to Santa Ana (California) | 1,245.36 mi (2,004.21 km) |
| Rio Grande City to Santa Barbara (California) | 1,360.33 mi (2,189.24 km) |
| Rio Grande City to Santa Clara (California) | 1,549.57 mi (2,493.78 km) |
| Rio Grande City to Santa Clara (Oregon) | 1,826.53 mi (2,939.51 km) |
| Rio Grande City to Santa Clarita (California) | 1,294.24 mi (2,082.87 km) |
| Rio Grande City to Santa Cruz (California) | 1,542.92 mi (2,483.08 km) |
| Rio Grande City to Santa Fe (New Mexico) | 768.17 mi (1,236.25 km) |
| Rio Grande City to Santa Fe (Texas) | 307.92 mi (495.56 km) |
| Rio Grande City to Santa Fe Springs (California) | 1,259.60 mi (2,027.13 km) |
| Rio Grande City to Santa Maria (California) | 1,410.40 mi (2,269.82 km) |
| Rio Grande City to Santa Monica (California) | 1,284.30 mi (2,066.88 km) |
| Rio Grande City to Santa Paula (California) | 1,323.35 mi (2,129.73 km) |
