| Rio Grande City to San Luis Obispo (California) | 1,430.02 mi (2,301.39 km) |
| Rio Grande City to San Marcos (California) | 1,193.43 mi (1,920.63 km) |
| Rio Grande City to San Marcos (Texas) | 247.28 mi (397.95 km) |
| Rio Grande City to San Marino (California) | 1,266.72 mi (2,038.58 km) |
| Rio Grande City to San Mateo (California) | 1,571.97 mi (2,529.84 km) |
| Rio Grande City to San Pablo (California) | 1,584.60 mi (2,550.16 km) |
| Rio Grande City to San Rafael (California) | 1,594.33 mi (2,565.82 km) |
| Rio Grande City to San Ramon (California) | 1,558.76 mi (2,508.58 km) |
| Rio Grande City to San Tan Valley (Arizona) | 895.81 mi (1,441.67 km) |
| Rio Grande City to Sand Springs (Oklahoma) | 692.39 mi (1,114.30 km) |
| Rio Grande City to Sandusky (Ohio) | 1,387.24 mi (2,232.54 km) |
| Rio Grande City to Sandy (Oregon) | 1,843.92 mi (2,967.51 km) |
| Rio Grande City to Sandy (Utah) | 1,231.94 mi (1,982.61 km) |
| Rio Grande City to Sandy Springs (Georgia) | 1,007.32 mi (1,621.12 km) |
| Rio Grande City to Sanford (Florida) | 1,086.26 mi (1,748.17 km) |
