| Rio Grande City to San Diego (California) | 1,184.15 mi (1,905.70 km) |
| Rio Grande City to San Diego Country Estates (California) | 1,169.43 mi (1,882.02 km) |
| Rio Grande City to San Dimas (California) | 1,250.03 mi (2,011.72 km) |
| Rio Grande City to San Fernando (California) | 1,287.97 mi (2,072.79 km) |
| Rio Grande City to San Francisco (California) | 1,584.10 mi (2,549.37 km) |
| Rio Grande City to San Gabriel (California) | 1,265.31 mi (2,036.32 km) |
| Rio Grande City to San Germán (Puerto Rico) | 2,105.32 mi (3,388.18 km) |
| Rio Grande City to San Jacinto (California) | 1,198.63 mi (1,929.01 km) |
| Rio Grande City to San Jose (California) | 1,541.79 mi (2,481.28 km) |
| Rio Grande City to San Juan (Puerto Rico) | 2,157.74 mi (3,472.54 km) |
| Rio Grande City to San Juan (Texas) | 43.51 mi (70.03 km) |
| Rio Grande City to San Juan Capistrano (California) | 1,227.71 mi (1,975.81 km) |
| Rio Grande City to San Leandro (California) | 1,568.46 mi (2,524.19 km) |
| Rio Grande City to San Lorenzo (California) | 1,566.19 mi (2,520.54 km) |
| Rio Grande City to San Luis (Arizona) | 1,043.58 mi (1,679.48 km) |
