| Rio Grande City to Salisbury (New York) | 1,750.38 mi (2,816.96 km) |
| Rio Grande City to Salisbury (North Carolina) | 1,257.59 mi (2,023.90 km) |
| Rio Grande City to Salmon Creek (Washington) | 1,872.10 mi (3,012.86 km) |
| Rio Grande City to Salt Lake City (Utah) | 1,245.47 mi (2,004.39 km) |
| Rio Grande City to Sammamish (Washington) | 1,931.97 mi (3,109.20 km) |
| Rio Grande City to San Angelo (Texas) | 363.32 mi (584.70 km) |
| Rio Grande City to San Anselmo (California) | 1,596.49 mi (2,569.30 km) |
| Rio Grande City to San Antonio (Texas) | 213.75 mi (343.99 km) |
| Rio Grande City to San Benito (Texas) | 75.00 mi (120.69 km) |
| Rio Grande City to San Bernardino (California) | 1,223.28 mi (1,968.68 km) |
| Rio Grande City to San Bruno (California) | 1,579.94 mi (2,542.67 km) |
| Rio Grande City to San Buenaventura (California) | 1,330.50 mi (2,141.24 km) |
| Rio Grande City to San Carlos (California) | 1,568.29 mi (2,523.92 km) |
| Rio Grande City to San Carlos Park (Florida) | 1,051.22 mi (1,691.77 km) |
| Rio Grande City to San Clemente (California) | 1,224.18 mi (1,970.12 km) |
