| Rio Grande City to Saddlebrooke (Arizona) | 840.42 mi (1,352.52 km) |
| Rio Grande City to Safety Harbor (Florida) | 996.60 mi (1,603.87 km) |
| Rio Grande City to Saginaw (Michigan) | 1,442.88 mi (2,322.10 km) |
| Rio Grande City to Saginaw (Texas) | 456.50 mi (734.67 km) |
| Rio Grande City to Sahuarita (Arizona) | 826.29 mi (1,329.78 km) |
| Rio Grande City to Saks (Alabama) | 925.10 mi (1,488.81 km) |
| Rio Grande City to Salem (Massachusetts) | 1,927.73 mi (3,102.38 km) |
| Rio Grande City to Salem (Ohio) | 1,435.15 mi (2,309.65 km) |
| Rio Grande City to Salem (Oregon) | 1,853.93 mi (2,983.62 km) |
| Rio Grande City to Salem (Virginia) | 1,330.51 mi (2,141.26 km) |
| Rio Grande City to Salem Lakes (Wisconsin) | 1,269.13 mi (2,042.46 km) |
| Rio Grande City to Salida (California) | 1,514.72 mi (2,437.70 km) |
| Rio Grande City to Salina (Kansas) | 861.87 mi (1,387.04 km) |
| Rio Grande City to Salinas (California) | 1,514.81 mi (2,437.85 km) |
| Rio Grande City to Salisbury (Maryland) | 1,582.04 mi (2,546.05 km) |
