| Rio Grande City to Reedley (California) | 1,400.88 mi (2,254.49 km) |
| Rio Grande City to Reidsville (North Carolina) | 1,318.96 mi (2,122.66 km) |
| Rio Grande City to Reisterstown (Maryland) | 1,556.70 mi (2,505.27 km) |
| Rio Grande City to Rendon (Texas) | 438.73 mi (706.07 km) |
| Rio Grande City to Reno (Nevada) | 1,514.53 mi (2,437.39 km) |
| Rio Grande City to Renton (Washington) | 1,931.68 mi (3,108.74 km) |
| Rio Grande City to Republic (Missouri) | 807.64 mi (1,299.77 km) |
| Rio Grande City to Reston (Virginia) | 1,514.95 mi (2,438.08 km) |
| Rio Grande City to Revere (Massachusetts) | 1,920.20 mi (3,090.26 km) |
| Rio Grande City to Rexburg (Idaho) | 1,406.67 mi (2,263.82 km) |
| Rio Grande City to Reynoldsburg (Ohio) | 1,314.70 mi (2,115.80 km) |
| Rio Grande City to Rialto (California) | 1,227.76 mi (1,975.89 km) |
| Rio Grande City to Richardson (Texas) | 472.67 mi (760.68 km) |
| Rio Grande City to Richfield (Minnesota) | 1,314.40 mi (2,115.32 km) |
| Rio Grande City to Richfield (Wisconsin) | 1,307.66 mi (2,104.47 km) |
