| Rio Grande City to Owosso (Michigan) | 1,413.16 mi (2,274.26 km) |
| Rio Grande City to Oxford (Alabama) | 920.42 mi (1,481.28 km) |
| Rio Grande City to Oxford (Mississippi) | 780.71 mi (1,256.43 km) |
| Rio Grande City to Oxford (Ohio) | 1,216.98 mi (1,958.54 km) |
| Rio Grande City to Oxnard (California) | 1,326.09 mi (2,134.13 km) |
| Rio Grande City to Oxon Hill (Maryland) | 1,527.42 mi (2,458.15 km) |
| Rio Grande City to Ozark (Alabama) | 869.54 mi (1,399.39 km) |
| Rio Grande City to Ozark (Missouri) | 806.18 mi (1,297.42 km) |
| Rio Grande City to Pace (Florida) | 765.33 mi (1,231.69 km) |
| Rio Grande City to Pacific Grove (California) | 1,528.26 mi (2,459.50 km) |
| Rio Grande City to Pacifica (California) | 1,581.94 mi (2,545.88 km) |
| Rio Grande City to Paducah (Kentucky) | 949.12 mi (1,527.46 km) |
| Rio Grande City to Pahrump (Nevada) | 1,217.88 mi (1,959.99 km) |
| Rio Grande City to Painesville (Ohio) | 1,455.45 mi (2,342.33 km) |
| Rio Grande City to Palatine (Illinois) | 1,247.06 mi (2,006.95 km) |
