| Rio Grande City to Medford (Massachusetts) | 1,915.55 mi (3,082.78 km) |
| Rio Grande City to Medford (New York) | 1,779.66 mi (2,864.08 km) |
| Rio Grande City to Medford (Oregon) | 1,748.21 mi (2,813.47 km) |
| Rio Grande City to Medina (Ohio) | 1,404.67 mi (2,260.60 km) |
| Rio Grande City to Medulla (Florida) | 1,039.72 mi (1,673.26 km) |
| Rio Grande City to Mehlville (Missouri) | 972.24 mi (1,564.67 km) |
| Rio Grande City to Melbourne (Florida) | 1,120.77 mi (1,803.71 km) |
| Rio Grande City to Melissa (Texas) | 496.19 mi (798.54 km) |
| Rio Grande City to Melrose (Massachusetts) | 1,918.81 mi (3,088.03 km) |
| Rio Grande City to Melrose Park (Illinois) | 1,239.66 mi (1,995.04 km) |
| Rio Grande City to Melville (New York) | 1,758.61 mi (2,830.22 km) |
| Rio Grande City to Melvindale (Michigan) | 1,410.51 mi (2,270.00 km) |
| Rio Grande City to Memphis (Florida) | 1,003.88 mi (1,615.59 km) |
| Rio Grande City to Memphis (Tennessee) | 799.32 mi (1,286.39 km) |
| Rio Grande City to Menasha (Wisconsin) | 1,361.70 mi (2,191.45 km) |
