| Rio Grande City to Lovington (New Mexico) | 526.06 mi (846.61 km) |
| Rio Grande City to Lowell (Indiana) | 1,217.98 mi (1,960.14 km) |
| Rio Grande City to Lowell (Massachusetts) | 1,912.57 mi (3,077.98 km) |
| Rio Grande City to Lower Burrell (Pennsylvania) | 1,468.80 mi (2,363.80 km) |
| Rio Grande City to Lowes Island (Virginia) | 1,517.88 mi (2,442.80 km) |
| Rio Grande City to Lubbock (Texas) | 529.18 mi (851.64 km) |
| Rio Grande City to Lufkin (Texas) | 421.71 mi (678.68 km) |
| Rio Grande City to Luling (Louisiana) | 570.21 mi (917.66 km) |
| Rio Grande City to Lumberton (North Carolina) | 1,306.19 mi (2,102.11 km) |
| Rio Grande City to Lumberton (Texas) | 387.83 mi (624.15 km) |
| Rio Grande City to Lutz (Florida) | 1,012.26 mi (1,629.07 km) |
| Rio Grande City to Lynbrook (New York) | 1,742.34 mi (2,804.02 km) |
| Rio Grande City to Lynchburg (Virginia) | 1,376.01 mi (2,214.47 km) |
| Rio Grande City to Lynden (Washington) | 2,008.16 mi (3,231.82 km) |
| Rio Grande City to Lyndhurst (Ohio) | 1,436.77 mi (2,312.25 km) |
