| Rio Grande City to Isabela (Puerto Rico) | 2,096.39 mi (3,373.81 km) |
| Rio Grande City to Iselin (New Jersey) | 1,709.53 mi (2,751.22 km) |
| Rio Grande City to Isla Vista (California) | 1,367.63 mi (2,200.99 km) |
| Rio Grande City to Issaquah (Washington) | 1,929.54 mi (3,105.29 km) |
| Rio Grande City to Ithaca (New York) | 1,678.68 mi (2,701.58 km) |
| Rio Grande City to Ives Estates (Florida) | 1,155.12 mi (1,858.99 km) |
| Rio Grande City to Jackson (Michigan) | 1,366.25 mi (2,198.76 km) |
| Rio Grande City to Jackson (Mississippi) | 660.59 mi (1,063.12 km) |
| Rio Grande City to Jackson (Missouri) | 929.94 mi (1,496.59 km) |
| Rio Grande City to Jackson (Tennessee) | 870.82 mi (1,401.45 km) |
| Rio Grande City to Jackson (Wyoming) | 1,357.95 mi (2,185.41 km) |
| Rio Grande City to Jacksonville (Alabama) | 933.37 mi (1,502.12 km) |
| Rio Grande City to Jacksonville (Arkansas) | 708.88 mi (1,140.83 km) |
| Rio Grande City to Jacksonville (Florida) | 1,076.48 mi (1,732.43 km) |
| Rio Grande City to Jacksonville (Illinois) | 1,046.60 mi (1,684.34 km) |
