| Rio Grande City to Indianapolis (Indiana) | 1,178.57 mi (1,896.72 km) |
| Rio Grande City to Indianola (Iowa) | 1,077.61 mi (1,734.25 km) |
| Rio Grande City to Indio (California) | 1,156.48 mi (1,861.17 km) |
| Rio Grande City to Inglewood (California) | 1,275.40 mi (2,052.56 km) |
| Rio Grande City to Inkster (Michigan) | 1,406.36 mi (2,263.31 km) |
| Rio Grande City to Inver Grove Heights (Minnesota) | 1,313.93 mi (2,114.56 km) |
| Rio Grande City to Inwood (New York) | 1,737.64 mi (2,796.46 km) |
| Rio Grande City to Iona (Florida) | 1,042.36 mi (1,677.52 km) |
| Rio Grande City to Ionia (Michigan) | 1,383.40 mi (2,226.37 km) |
| Rio Grande City to Iowa City (Iowa) | 1,133.89 mi (1,824.82 km) |
| Rio Grande City to Irmo (South Carolina) | 1,177.24 mi (1,894.58 km) |
| Rio Grande City to Irondale (Alabama) | 879.19 mi (1,414.91 km) |
| Rio Grande City to Ironton (Ohio) | 1,257.64 mi (2,023.98 km) |
| Rio Grande City to Irvine (California) | 1,238.14 mi (1,992.60 km) |
| Rio Grande City to Irving (Texas) | 461.13 mi (742.12 km) |
