| Rio Grande City to Enterprise (Nevada) | 1,173.21 mi (1,888.09 km) |
| Rio Grande City to Enumclaw (Washington) | 1,912.05 mi (3,077.15 km) |
| Rio Grande City to Ephrata (Pennsylvania) | 1,610.44 mi (2,591.76 km) |
| Rio Grande City to Erie (Colorado) | 1,009.21 mi (1,624.17 km) |
| Rio Grande City to Erie (Pennsylvania) | 1,519.23 mi (2,444.96 km) |
| Rio Grande City to Erlanger (Kentucky) | 1,199.74 mi (1,930.79 km) |
| Rio Grande City to Escanaba (Michigan) | 1,486.17 mi (2,391.77 km) |
| Rio Grande City to Escondido (California) | 1,187.82 mi (1,911.61 km) |
| Rio Grande City to Española (New Mexico) | 790.33 mi (1,271.92 km) |
| Rio Grande City to Essex (Maryland) | 1,569.03 mi (2,525.10 km) |
| Rio Grande City to Essex Junction (Vermont) | 1,898.36 mi (3,055.12 km) |
| Rio Grande City to Estelle (Louisiana) | 582.55 mi (937.52 km) |
| Rio Grande City to Estero (Florida) | 1,052.92 mi (1,694.51 km) |
| Rio Grande City to Euclid (Ohio) | 1,439.07 mi (2,315.96 km) |
| Rio Grande City to Eufaula (Alabama) | 908.16 mi (1,461.54 km) |
