| Rio Grande City to Elyria (Ohio) | 1,406.55 mi (2,263.63 km) |
| Rio Grande City to Emeryville (California) | 1,578.71 mi (2,540.69 km) |
| Rio Grande City to Emmaus (Pennsylvania) | 1,653.79 mi (2,661.51 km) |
| Rio Grande City to Emporia (Kansas) | 844.56 mi (1,359.19 km) |
| Rio Grande City to Encinitas (California) | 1,196.37 mi (1,925.37 km) |
| Rio Grande City to Endicott (New York) | 1,684.17 mi (2,710.42 km) |
| Rio Grande City to Endwell (New York) | 1,686.75 mi (2,714.56 km) |
| Rio Grande City to Englewood (Colorado) | 983.21 mi (1,582.33 km) |
| Rio Grande City to Englewood (Florida) | 1,016.89 mi (1,636.52 km) |
| Rio Grande City to Englewood (New Jersey) | 1,735.75 mi (2,793.42 km) |
| Rio Grande City to Englewood (Ohio) | 1,250.91 mi (2,013.14 km) |
| Rio Grande City to Enid (Oklahoma) | 694.95 mi (1,118.42 km) |
| Rio Grande City to Ennis (Texas) | 431.29 mi (694.10 km) |
| Rio Grande City to Ensley (Florida) | 757.21 mi (1,218.62 km) |
| Rio Grande City to Enterprise (Alabama) | 855.57 mi (1,376.91 km) |
