| Rio Grande City to Effingham (Illinois) | 1,061.80 mi (1,708.80 km) |
| Rio Grande City to Eggertsville (New York) | 1,606.32 mi (2,585.13 km) |
| Rio Grande City to Egypt Lake-Leto (Florida) | 1,008.22 mi (1,622.57 km) |
| Rio Grande City to El Cajon (California) | 1,174.57 mi (1,890.29 km) |
| Rio Grande City to El Campo (Texas) | 249.42 mi (401.41 km) |
| Rio Grande City to El Centro (California) | 1,097.05 mi (1,765.53 km) |
| Rio Grande City to El Cerrito (California) | 1,581.40 mi (2,545.02 km) |
| Rio Grande City to El Dorado (Arkansas) | 599.28 mi (964.45 km) |
| Rio Grande City to El Dorado (Kansas) | 798.66 mi (1,285.33 km) |
| Rio Grande City to El Dorado Hills (California) | 1,541.99 mi (2,481.59 km) |
| Rio Grande City to El Mirage (Arizona) | 948.11 mi (1,525.84 km) |
| Rio Grande City to El Monte (California) | 1,261.05 mi (2,029.47 km) |
| Rio Grande City to El Paso (Texas) | 594.33 mi (956.48 km) |
| Rio Grande City to El Paso de Robles (California) | 1,438.07 mi (2,314.35 km) |
| Rio Grande City to El Reno (Oklahoma) | 635.06 mi (1,022.03 km) |
