| Rio Grande City to Eatontown (New Jersey) | 1,713.06 mi (2,756.91 km) |
| Rio Grande City to Eau Claire (Wisconsin) | 1,337.42 mi (2,152.37 km) |
| Rio Grande City to Echelon (New Jersey) | 1,654.91 mi (2,663.32 km) |
| Rio Grande City to Eden (North Carolina) | 1,320.59 mi (2,125.29 km) |
| Rio Grande City to Eden Prairie (Minnesota) | 1,310.30 mi (2,108.73 km) |
| Rio Grande City to Edgewater (Florida) | 1,107.45 mi (1,782.27 km) |
| Rio Grande City to Edgewater (New Jersey) | 1,733.57 mi (2,789.90 km) |
| Rio Grande City to Edgewood (Maryland) | 1,579.82 mi (2,542.47 km) |
| Rio Grande City to Edgewood (Washington) | 1,923.84 mi (3,096.12 km) |
| Rio Grande City to Edina (Minnesota) | 1,314.41 mi (2,115.34 km) |
| Rio Grande City to Edinburg (Texas) | 41.19 mi (66.29 km) |
| Rio Grande City to Edmond (Oklahoma) | 647.09 mi (1,041.40 km) |
| Rio Grande City to Edmonds (Washington) | 1,952.42 mi (3,142.11 km) |
| Rio Grande City to Edwards (Colorado) | 1,019.27 mi (1,640.35 km) |
| Rio Grande City to Edwardsville (Illinois) | 998.71 mi (1,607.27 km) |
