| Rio Grande City to Duluth (Minnesota) | 1,455.75 mi (2,342.81 km) |
| Rio Grande City to Dumas (Texas) | 680.78 mi (1,095.61 km) |
| Rio Grande City to Dumont (New Jersey) | 1,736.60 mi (2,794.79 km) |
| Rio Grande City to Duncan (Oklahoma) | 566.33 mi (911.43 km) |
| Rio Grande City to Duncanville (Texas) | 447.81 mi (720.68 km) |
| Rio Grande City to Dundalk (Maryland) | 1,565.67 mi (2,519.70 km) |
| Rio Grande City to Dunedin (Florida) | 991.21 mi (1,595.20 km) |
| Rio Grande City to Dunkirk (New York) | 1,564.42 mi (2,517.69 km) |
| Rio Grande City to Dunmore (Pennsylvania) | 1,679.23 mi (2,702.46 km) |
| Rio Grande City to Dunwoody (Georgia) | 1,010.44 mi (1,626.15 km) |
| Rio Grande City to Durango (Colorado) | 919.96 mi (1,480.53 km) |
| Rio Grande City to Durant (Oklahoma) | 545.66 mi (878.16 km) |
| Rio Grande City to Durham (North Carolina) | 1,347.47 mi (2,168.54 km) |
| Rio Grande City to Dyer (Indiana) | 1,226.87 mi (1,974.46 km) |
| Rio Grande City to Dyersburg (Tennessee) | 869.30 mi (1,399.00 km) |
