| Rio Grande City to Des Plaines (Illinois) | 1,246.19 mi (2,005.56 km) |
| Rio Grande City to Desert Hot Springs (California) | 1,178.52 mi (1,896.65 km) |
| Rio Grande City to DeSoto (Texas) | 445.47 mi (716.91 km) |
| Rio Grande City to Destin (Florida) | 799.79 mi (1,287.14 km) |
| Rio Grande City to Destrehan (Louisiana) | 571.06 mi (919.04 km) |
| Rio Grande City to Detroit (Michigan) | 1,418.34 mi (2,282.60 km) |
| Rio Grande City to Diamond Bar (California) | 1,247.83 mi (2,008.19 km) |
| Rio Grande City to Diamond Springs (California) | 1,532.43 mi (2,466.21 km) |
| Rio Grande City to Dickinson (North Dakota) | 1,433.69 mi (2,307.30 km) |
| Rio Grande City to Dickinson (Texas) | 312.81 mi (503.42 km) |
| Rio Grande City to Dickson (Tennessee) | 950.25 mi (1,529.29 km) |
| Rio Grande City to Difficult Run (Virginia) | 1,513.32 mi (2,435.45 km) |
| Rio Grande City to Dinuba (California) | 1,396.91 mi (2,248.10 km) |
| Rio Grande City to Discovery Bay (California) | 1,545.96 mi (2,487.98 km) |
| Rio Grande City to Dix Hills (New York) | 1,762.60 mi (2,836.63 km) |
