| Rio Grande City to Delaware (Ohio) | 1,318.47 mi (2,121.87 km) |
| Rio Grande City to Delhi (California) | 1,491.39 mi (2,400.16 km) |
| Rio Grande City to Delray Beach (Florida) | 1,158.02 mi (1,863.65 km) |
| Rio Grande City to Deltona (Florida) | 1,090.67 mi (1,755.27 km) |
| Rio Grande City to Deming (New Mexico) | 673.80 mi (1,084.38 km) |
| Rio Grande City to Denison (Texas) | 527.60 mi (849.08 km) |
| Rio Grande City to Dent (Ohio) | 1,205.30 mi (1,939.74 km) |
| Rio Grande City to Denton (Texas) | 482.96 mi (777.25 km) |
| Rio Grande City to Dentsville (South Carolina) | 1,189.33 mi (1,914.05 km) |
| Rio Grande City to Denver (Colorado) | 988.11 mi (1,590.21 km) |
| Rio Grande City to Depew (New York) | 1,607.97 mi (2,587.78 km) |
| Rio Grande City to Derby (Connecticut) | 1,790.72 mi (2,881.88 km) |
| Rio Grande City to Derby (Kansas) | 777.61 mi (1,251.44 km) |
| Rio Grande City to Des Moines (Iowa) | 1,090.71 mi (1,755.32 km) |
| Rio Grande City to Des Moines (Washington) | 1,932.17 mi (3,109.53 km) |
