| Rio Grande City to Cordele (Georgia) | 985.23 mi (1,585.58 km) |
| Rio Grande City to Corinth (Mississippi) | 850.82 mi (1,369.26 km) |
| Rio Grande City to Corinth (Texas) | 478.91 mi (770.73 km) |
| Rio Grande City to Cornelius (North Carolina) | 1,232.01 mi (1,982.72 km) |
| Rio Grande City to Cornelius (Oregon) | 1,879.17 mi (3,024.22 km) |
| Rio Grande City to Corning (New York) | 1,643.76 mi (2,645.38 km) |
| Rio Grande City to Corona (California) | 1,231.06 mi (1,981.20 km) |
| Rio Grande City to Coronado (California) | 1,182.90 mi (1,903.70 km) |
| Rio Grande City to Corpus Christi (Texas) | 128.58 mi (206.94 km) |
| Rio Grande City to Corsicana (Texas) | 418.71 mi (673.85 km) |
| Rio Grande City to Cortland (New York) | 1,698.43 mi (2,733.35 km) |
| Rio Grande City to Corvallis (Oregon) | 1,850.08 mi (2,977.42 km) |
| Rio Grande City to Coshocton (Ohio) | 1,366.45 mi (2,199.09 km) |
| Rio Grande City to Costa Mesa (California) | 1,245.51 mi (2,004.46 km) |
| Rio Grande City to Coto de Caza (California) | 1,226.10 mi (1,973.22 km) |
