| Rio Grande City to Candler-McAfee (Georgia) | 1,005.77 mi (1,618.64 km) |
| Rio Grande City to Caño Martin Peña (Puerto Rico) | 2,157.58 mi (3,472.28 km) |
| Rio Grande City to Cañon City (Colorado) | 912.53 mi (1,468.58 km) |
| Rio Grande City to Canóvanas (Puerto Rico) | 2,168.27 mi (3,489.49 km) |
| Rio Grande City to Canton (Georgia) | 1,011.35 mi (1,627.60 km) |
| Rio Grande City to Canton (Illinois) | 1,101.43 mi (1,772.57 km) |
| Rio Grande City to Canton (Mississippi) | 680.65 mi (1,095.40 km) |
| Rio Grande City to Canton (Ohio) | 1,409.91 mi (2,269.03 km) |
| Rio Grande City to Canyon (Texas) | 622.63 mi (1,002.02 km) |
| Rio Grande City to Canyon Lake (California) | 1,210.65 mi (1,948.35 km) |
| Rio Grande City to Canyon Lake (Texas) | 243.90 mi (392.52 km) |
| Rio Grande City to Cape Coral (Florida) | 1,039.70 mi (1,673.24 km) |
| Rio Grande City to Cape Girardeau (Missouri) | 929.36 mi (1,495.66 km) |
| Rio Grande City to Carbondale (Illinois) | 963.07 mi (1,549.91 km) |
| Rio Grande City to Carlisle (Pennsylvania) | 1,564.46 mi (2,517.75 km) |
