| Rio Grande City to Anoka (Minnesota) | 1,335.30 mi (2,148.95 km) |
| Rio Grande City to Ansonia (Connecticut) | 1,791.94 mi (2,883.85 km) |
| Rio Grande City to Antelope (California) | 1,558.28 mi (2,507.80 km) |
| Rio Grande City to Anthem (Arizona) | 946.37 mi (1,523.04 km) |
| Rio Grande City to Antioch (California) | 1,557.80 mi (2,507.04 km) |
| Rio Grande City to Antioch (Illinois) | 1,267.04 mi (2,039.11 km) |
| Rio Grande City to Apache Junction (Arizona) | 901.70 mi (1,451.15 km) |
| Rio Grande City to Apex (North Carolina) | 1,341.85 mi (2,159.50 km) |
| Rio Grande City to Apollo Beach (Florida) | 1,014.02 mi (1,631.91 km) |
| Rio Grande City to Apopka (Florida) | 1,070.32 mi (1,722.52 km) |
| Rio Grande City to Apple Valley (California) | 1,228.90 mi (1,977.72 km) |
| Rio Grande City to Apple Valley (Minnesota) | 1,306.79 mi (2,103.07 km) |
| Rio Grande City to Appleton (Wisconsin) | 1,366.57 mi (2,199.29 km) |
| Rio Grande City to Arbutus (Maryland) | 1,555.43 mi (2,503.22 km) |
| Rio Grande City to Arcadia (California) | 1,262.91 mi (2,032.46 km) |
