| Rio Grande City to Altus (Oklahoma) | 572.52 mi (921.38 km) |
| Rio Grande City to Alum Rock (California) | 1,542.39 mi (2,482.24 km) |
| Rio Grande City to Alvin (Texas) | 299.23 mi (481.57 km) |
| Rio Grande City to Amarillo (Texas) | 634.79 mi (1,021.60 km) |
| Rio Grande City to Amelia (Ohio) | 1,215.02 mi (1,955.38 km) |
| Rio Grande City to American Canyon (California) | 1,586.42 mi (2,553.10 km) |
| Rio Grande City to American Fork (Utah) | 1,220.03 mi (1,963.46 km) |
| Rio Grande City to Americus (Georgia) | 962.87 mi (1,549.59 km) |
| Rio Grande City to Ames (Iowa) | 1,120.45 mi (1,803.19 km) |
| Rio Grande City to Amherst (Ohio) | 1,403.01 mi (2,257.93 km) |
| Rio Grande City to Ammon (Idaho) | 1,391.98 mi (2,240.17 km) |
| Rio Grande City to Amsterdam (New York) | 1,795.97 mi (2,890.33 km) |
| Rio Grande City to Anacortes (Washington) | 1,992.76 mi (3,207.03 km) |
| Rio Grande City to Anaheim (California) | 1,246.35 mi (2,005.81 km) |
| Rio Grande City to Anchorage (Alaska) | 3,336.44 mi (5,369.49 km) |
