| Reston to Southern Pines (North Carolina) | 283.27 mi (455.87 km) |
| Reston to Southfield (Michigan) | 393.94 mi (633.98 km) |
| Reston to Southgate (Michigan) | 380.82 mi (612.86 km) |
| Reston to Southlake (Texas) | 1,179.58 mi (1,898.35 km) |
| Reston to Spanaway (Washington) | 2,311.38 mi (3,719.81 km) |
| Reston to Spanish Fork (Utah) | 1,817.99 mi (2,925.77 km) |
| Reston to Spanish Lake (Missouri) | 691.40 mi (1,112.71 km) |
| Reston to Spanish Springs (Nevada) | 2,242.02 mi (3,608.18 km) |
| Reston to Sparks (Nevada) | 2,245.70 mi (3,614.11 km) |
| Reston to Spartanburg (South Carolina) | 374.76 mi (603.11 km) |
| Reston to Spearfish (South Dakota) | 1,410.77 mi (2,270.41 km) |
| Reston to Speedway (Indiana) | 478.84 mi (770.61 km) |
| Reston to Spencer (Iowa) | 969.95 mi (1,560.99 km) |
| Reston to Spokane (Washington) | 2,077.69 mi (3,343.72 km) |
| Reston to Spokane Valley (Washington) | 2,068.45 mi (3,328.85 km) |
