| Reston to Sacile | 4,355.49 mi (7,009.49 km) |
| Reston to Sala Consilina | 4,688.15 mi (7,544.85 km) |
| Reston to Salemi | 4,658.69 mi (7,497.44 km) |
| Reston to Salerno | 4,640.55 mi (7,468.25 km) |
| Reston to Salo | 4,284.65 mi (6,895.48 km) |
| Reston to Salsomaggiore Terme | 4,286.72 mi (6,898.82 km) |
| Reston to Saluzzo | 4,184.12 mi (6,733.70 km) |
| Reston to Salzano | 4,353.99 mi (7,007.07 km) |
| Reston to Samarate | 4,209.34 mi (6,774.27 km) |
| Reston to San Benedetto del Tronto | 4,519.42 mi (7,273.31 km) |
| Reston to San Biagio di Callalta | 4,359.97 mi (7,016.70 km) |
| Reston to San Bonifacio | 4,323.15 mi (6,957.44 km) |
| Reston to San Casciano in Val di Pesa | 4,377.73 mi (7,045.27 km) |
| Reston to San Cataldo | 4,725.54 mi (7,605.03 km) |
| Reston to San Cesareo | 4,512.67 mi (7,262.44 km) |
