| Reno to Southern Pines (North Carolina) | 2,222.30 mi (3,576.44 km) |
| Reno to Southfield (Michigan) | 1,903.34 mi (3,063.13 km) |
| Reno to Southgate (Michigan) | 1,908.30 mi (3,071.12 km) |
| Reno to Southlake (Texas) | 1,339.82 mi (2,156.22 km) |
| Reno to Spanaway (Washington) | 537.27 mi (864.65 km) |
| Reno to Spanish Fork (Utah) | 437.07 mi (703.39 km) |
| Reno to Spanish Lake (Missouri) | 1,581.43 mi (2,545.07 km) |
| Reno to Spanish Springs (Nevada) | 12.06 mi (19.41 km) |
| Reno to Sparks (Nevada) | 7.23 mi (11.64 km) |
| Reno to Spartanburg (South Carolina) | 2,094.25 mi (3,370.37 km) |
| Reno to Spearfish (South Dakota) | 889.04 mi (1,430.77 km) |
| Reno to Speedway (Indiana) | 1,776.37 mi (2,858.80 km) |
| Reno to Spencer (Iowa) | 1,299.81 mi (2,091.84 km) |
| Reno to Spokane (Washington) | 573.65 mi (923.19 km) |
| Reno to Spokane Valley (Washington) | 575.50 mi (926.18 km) |
