| Redding to Southern Pines (North Carolina) | 2,348.60 mi (3,779.70 km) |
| Redding to Southfield (Michigan) | 2,009.19 mi (3,233.48 km) |
| Redding to Southgate (Michigan) | 2,015.18 mi (3,243.13 km) |
| Redding to Southlake (Texas) | 1,485.18 mi (2,390.16 km) |
| Redding to Spanaway (Washington) | 451.06 mi (725.91 km) |
| Redding to Spanish Fork (Utah) | 565.34 mi (909.82 km) |
| Redding to Spanish Lake (Missouri) | 1,704.94 mi (2,743.84 km) |
| Redding to Spanish Springs (Nevada) | 155.77 mi (250.69 km) |
| Redding to Sparks (Nevada) | 156.05 mi (251.13 km) |
| Redding to Spartanburg (South Carolina) | 2,223.11 mi (3,577.75 km) |
| Redding to Spearfish (South Dakota) | 980.11 mi (1,577.34 km) |
| Redding to Speedway (Indiana) | 1,893.81 mi (3,047.79 km) |
| Redding to Spencer (Iowa) | 1,405.32 mi (2,261.64 km) |
| Redding to Spokane (Washington) | 547.73 mi (881.48 km) |
| Redding to Spokane Valley (Washington) | 551.90 mi (888.19 km) |
