| Rancho Santa Margarita to Yonkers (New York) | 2,430.34 mi (3,911.25 km) |
| Rancho Santa Margarita to Yorba Linda (California) | 20.35 mi (32.75 km) |
| Rancho Santa Margarita to York (Pennsylvania) | 2,282.52 mi (3,673.36 km) |
| Rancho Santa Margarita to Yorktown (Indiana) | 1,818.79 mi (2,927.06 km) |
| Rancho Santa Margarita to Yorkville (Illinois) | 1,678.71 mi (2,701.62 km) |
| Rancho Santa Margarita to Youngstown (Ohio) | 2,077.04 mi (3,342.68 km) |
| Rancho Santa Margarita to Youngsville (Louisiana) | 1,518.09 mi (2,443.13 km) |
| Rancho Santa Margarita to Ypsilanti (Michigan) | 1,930.12 mi (3,106.23 km) |
| Rancho Santa Margarita to Yuba City (California) | 441.58 mi (710.65 km) |
| Rancho Santa Margarita to Yucaipa (California) | 42.29 mi (68.06 km) |
| Rancho Santa Margarita to Yucca Valley (California) | 75.59 mi (121.65 km) |
| Rancho Santa Margarita to Yukon (Oklahoma) | 1,133.98 mi (1,824.96 km) |
| Rancho Santa Margarita to Yulee (Florida) | 2,107.71 mi (3,392.02 km) |
| Rancho Santa Margarita to Yuma (Arizona) | 190.34 mi (306.33 km) |
| Rancho Santa Margarita to Zachary (Louisiana) | 1,555.71 mi (2,503.68 km) |
