| Rancho Santa Margarita to Worthington (Ohio) | 1,949.85 mi (3,137.98 km) |
| Rancho Santa Margarita to Wright (Florida) | 1,819.68 mi (2,928.49 km) |
| Rancho Santa Margarita to Wyandanch (New York) | 2,457.29 mi (3,954.62 km) |
| Rancho Santa Margarita to Wyandotte (Michigan) | 1,953.51 mi (3,143.87 km) |
| Rancho Santa Margarita to Wylie (Texas) | 1,215.62 mi (1,956.34 km) |
| Rancho Santa Margarita to Wyndham (Virginia) | 2,245.12 mi (3,613.17 km) |
| Rancho Santa Margarita to Wyoming (Michigan) | 1,831.41 mi (2,947.37 km) |
| Rancho Santa Margarita to Wyomissing (Pennsylvania) | 2,321.79 mi (3,736.55 km) |
| Rancho Santa Margarita to Xenia (Ohio) | 1,900.05 mi (3,057.83 km) |
| Rancho Santa Margarita to Yakima (Washington) | 908.78 mi (1,462.54 km) |
| Rancho Santa Margarita to Yankton (South Dakota) | 1,264.35 mi (2,034.78 km) |
| Rancho Santa Margarita to Yauco (Puerto Rico) | 3,298.38 mi (5,308.24 km) |
| Rancho Santa Margarita to Yazoo City (Mississippi) | 1,567.59 mi (2,522.80 km) |
| Rancho Santa Margarita to Yeadon (Pennsylvania) | 2,360.87 mi (3,799.46 km) |
| Rancho Santa Margarita to Yelm (Washington) | 956.38 mi (1,539.14 km) |
