| Rancho Santa Margarita to Vinings (Georgia) | 1,895.08 mi (3,049.83 km) |
| Rancho Santa Margarita to Virginia Beach (Virginia) | 2,338.15 mi (3,762.89 km) |
| Rancho Santa Margarita to Visalia (California) | 210.38 mi (338.57 km) |
| Rancho Santa Margarita to Vista (California) | 36.95 mi (59.46 km) |
| Rancho Santa Margarita to Wabash (Indiana) | 1,805.81 mi (2,906.17 km) |
| Rancho Santa Margarita to Waco (Texas) | 1,194.74 mi (1,922.74 km) |
| Rancho Santa Margarita to Waconia (Minnesota) | 1,482.70 mi (2,386.18 km) |
| Rancho Santa Margarita to Wade Hampton (South Carolina) | 2,005.34 mi (3,227.28 km) |
| Rancho Santa Margarita to Wadsworth (Ohio) | 2,020.30 mi (3,251.36 km) |
| Rancho Santa Margarita to Waggaman (Louisiana) | 1,622.40 mi (2,611.00 km) |
| Rancho Santa Margarita to Wahiawa (Hawaii) | 2,594.76 mi (4,175.86 km) |
| Rancho Santa Margarita to Waianae (Hawaii) | 2,605.18 mi (4,192.63 km) |
| Rancho Santa Margarita to Waihee-Waiehu (Hawaii) | 2,527.92 mi (4,068.29 km) |
| Rancho Santa Margarita to Wailuku (Hawaii) | 2,529.07 mi (4,070.14 km) |
| Rancho Santa Margarita to Waimalu (Hawaii) | 2,593.55 mi (4,173.92 km) |
