| Rancho Santa Margarita to University Place (Washington) | 973.37 mi (1,566.49 km) |
| Rancho Santa Margarita to Upland (California) | 33.76 mi (54.34 km) |
| Rancho Santa Margarita to Upper Arlington (Ohio) | 1,947.06 mi (3,133.49 km) |
| Rancho Santa Margarita to Upper Grand Lagoon (Florida) | 1,876.56 mi (3,020.03 km) |
| Rancho Santa Margarita to Upper Montclair (New Jersey) | 2,413.24 mi (3,883.73 km) |
| Rancho Santa Margarita to Urbana (Illinois) | 1,677.11 mi (2,699.05 km) |
| Rancho Santa Margarita to Urbana (Maryland) | 2,251.92 mi (3,624.11 km) |
| Rancho Santa Margarita to Urbana (Ohio) | 1,911.18 mi (3,075.74 km) |
| Rancho Santa Margarita to Urbandale (Iowa) | 1,409.79 mi (2,268.83 km) |
| Rancho Santa Margarita to Utica (New York) | 2,359.55 mi (3,797.33 km) |
| Rancho Santa Margarita to Uvalde (Texas) | 1,092.47 mi (1,758.17 km) |
| Rancho Santa Margarita to Vacaville (California) | 407.68 mi (656.10 km) |
| Rancho Santa Margarita to Vadnais Heights (Minnesota) | 1,520.68 mi (2,447.29 km) |
| Rancho Santa Margarita to Vail (Arizona) | 415.96 mi (669.43 km) |
| Rancho Santa Margarita to Valdosta (Georgia) | 2,005.70 mi (3,227.87 km) |
