| Rancho Santa Margarita to The Villages (Florida) | 2,117.76 mi (3,408.21 km) |
| Rancho Santa Margarita to The Woodlands (Texas) | 1,314.66 mi (2,115.73 km) |
| Rancho Santa Margarita to Thibodaux (Louisiana) | 1,591.87 mi (2,561.86 km) |
| Rancho Santa Margarita to Thomasville (Georgia) | 1,965.75 mi (3,163.57 km) |
| Rancho Santa Margarita to Thomasville (North Carolina) | 2,122.40 mi (3,415.67 km) |
| Rancho Santa Margarita to Thonotosassa (Florida) | 2,119.36 mi (3,410.77 km) |
| Rancho Santa Margarita to Thornton (Colorado) | 822.93 mi (1,324.38 km) |
| Rancho Santa Margarita to Thousand Oaks (California) | 82.79 mi (133.24 km) |
| Rancho Santa Margarita to Three Lakes (Florida) | 2,288.05 mi (3,682.25 km) |
| Rancho Santa Margarita to Tiffin (Ohio) | 1,945.40 mi (3,130.81 km) |
| Rancho Santa Margarita to Tifton (Georgia) | 1,981.54 mi (3,188.99 km) |
| Rancho Santa Margarita to Tigard (Oregon) | 859.85 mi (1,383.79 km) |
| Rancho Santa Margarita to Tillmans Corner (Alabama) | 1,726.88 mi (2,779.15 km) |
| Rancho Santa Margarita to Timberlake (Virginia) | 2,158.08 mi (3,473.10 km) |
| Rancho Santa Margarita to Timberlane (Louisiana) | 1,635.34 mi (2,631.82 km) |
