| Rancho Santa Margarita to Superior (Colorado) | 813.36 mi (1,308.97 km) |
| Rancho Santa Margarita to Superior (Wisconsin) | 1,610.12 mi (2,591.23 km) |
| Rancho Santa Margarita to Surprise (Arizona) | 296.02 mi (476.39 km) |
| Rancho Santa Margarita to Susanville (California) | 497.57 mi (800.76 km) |
| Rancho Santa Margarita to Sussex (Wisconsin) | 1,709.99 mi (2,751.96 km) |
| Rancho Santa Margarita to Suwanee (Georgia) | 1,915.72 mi (3,083.06 km) |
| Rancho Santa Margarita to Swansea (Illinois) | 1,572.40 mi (2,530.53 km) |
| Rancho Santa Margarita to Sweetwater (Florida) | 2,285.76 mi (3,678.57 km) |
| Rancho Santa Margarita to Sweetwater (Texas) | 997.59 mi (1,605.47 km) |
| Rancho Santa Margarita to Sycamore (Illinois) | 1,671.14 mi (2,689.44 km) |
| Rancho Santa Margarita to Sylacauga (Alabama) | 1,800.86 mi (2,898.21 km) |
| Rancho Santa Margarita to Sylvania (Ohio) | 1,921.64 mi (3,092.57 km) |
| Rancho Santa Margarita to Syosset (New York) | 2,449.81 mi (3,942.59 km) |
| Rancho Santa Margarita to Syracuse (New York) | 2,313.13 mi (3,722.62 km) |
| Rancho Santa Margarita to Syracuse (Utah) | 597.55 mi (961.67 km) |
