| Rancho Santa Margarita to Sumter (South Carolina) | 2,124.72 mi (3,419.40 km) |
| Rancho Santa Margarita to Sun City (Arizona) | 305.87 mi (492.24 km) |
| Rancho Santa Margarita to Sun City Center (Florida) | 2,123.27 mi (3,417.07 km) |
| Rancho Santa Margarita to Sun City West (Arizona) | 301.45 mi (485.13 km) |
| Rancho Santa Margarita to Sun Lakes (Arizona) | 331.58 mi (533.63 km) |
| Rancho Santa Margarita to Sun Prairie (Wisconsin) | 1,661.02 mi (2,673.16 km) |
| Rancho Santa Margarita to Sun Valley (Nevada) | 430.34 mi (692.56 km) |
| Rancho Santa Margarita to Sun Village (California) | 67.28 mi (108.28 km) |
| Rancho Santa Margarita to Sunland Park (New Mexico) | 651.35 mi (1,048.25 km) |
| Rancho Santa Margarita to Sunny Isles Beach (Florida) | 2,295.96 mi (3,694.98 km) |
| Rancho Santa Margarita to Sunnyside (Washington) | 885.47 mi (1,425.03 km) |
| Rancho Santa Margarita to Sunnyvale (California) | 359.33 mi (578.29 km) |
| Rancho Santa Margarita to Sunrise (Florida) | 2,280.24 mi (3,669.68 km) |
| Rancho Santa Margarita to Sunrise Manor (Nevada) | 227.66 mi (366.38 km) |
| Rancho Santa Margarita to Sunset (Florida) | 2,289.01 mi (3,683.81 km) |
