| Rancho Santa Margarita to Sugar Hill (Georgia) | 1,915.85 mi (3,083.27 km) |
| Rancho Santa Margarita to Sugar Land (Texas) | 1,319.39 mi (2,123.35 km) |
| Rancho Santa Margarita to Sugarland Run (Virginia) | 2,251.16 mi (3,622.89 km) |
| Rancho Santa Margarita to Sugarmill Woods (Florida) | 2,092.03 mi (3,366.79 km) |
| Rancho Santa Margarita to Suisun City (California) | 403.08 mi (648.69 km) |
| Rancho Santa Margarita to Suitland (Maryland) | 2,276.25 mi (3,663.28 km) |
| Rancho Santa Margarita to Sulphur (Louisiana) | 1,437.44 mi (2,313.34 km) |
| Rancho Santa Margarita to Sulphur Springs (Texas) | 1,266.49 mi (2,038.22 km) |
| Rancho Santa Margarita to Summerfield (Maryland) | 2,278.95 mi (3,667.61 km) |
| Rancho Santa Margarita to Summerfield (North Carolina) | 2,129.89 mi (3,427.72 km) |
| Rancho Santa Margarita to Summerlin South (Nevada) | 214.83 mi (345.73 km) |
| Rancho Santa Margarita to Summerville (South Carolina) | 2,148.98 mi (3,458.44 km) |
| Rancho Santa Margarita to Summit (Illinois) | 1,712.57 mi (2,756.11 km) |
| Rancho Santa Margarita to Summit (New Jersey) | 2,405.03 mi (3,870.52 km) |
| Rancho Santa Margarita to Sumner (Washington) | 969.45 mi (1,560.18 km) |
