| Rancho Santa Margarita to Storm Lake (Iowa) | 1,361.57 mi (2,191.24 km) |
| Rancho Santa Margarita to Storrs (Connecticut) | 2,511.67 mi (4,042.14 km) |
| Rancho Santa Margarita to Stoughton (Wisconsin) | 1,657.50 mi (2,667.49 km) |
| Rancho Santa Margarita to Stow (Ohio) | 2,036.32 mi (3,277.15 km) |
| Rancho Santa Margarita to Streamwood (Illinois) | 1,696.91 mi (2,730.91 km) |
| Rancho Santa Margarita to Streator (Illinois) | 1,653.37 mi (2,660.85 km) |
| Rancho Santa Margarita to Streetsboro (Ohio) | 2,041.16 mi (3,284.94 km) |
| Rancho Santa Margarita to Strongsville (Ohio) | 2,016.27 mi (3,244.88 km) |
| Rancho Santa Margarita to Stuart (Florida) | 2,257.19 mi (3,632.59 km) |
| Rancho Santa Margarita to Stuarts Draft (Virginia) | 2,165.95 mi (3,485.76 km) |
| Rancho Santa Margarita to Sturgis (Michigan) | 1,834.80 mi (2,952.83 km) |
| Rancho Santa Margarita to Suamico (Wisconsin) | 1,742.82 mi (2,804.79 km) |
| Rancho Santa Margarita to Sudley (Virginia) | 2,245.70 mi (3,614.11 km) |
| Rancho Santa Margarita to Suffern (New York) | 2,415.58 mi (3,887.50 km) |
| Rancho Santa Margarita to Suffolk (Virginia) | 2,305.72 mi (3,710.69 km) |
