| Rancho Santa Margarita to Stephenville (Texas) | 1,126.48 mi (1,812.90 km) |
| Rancho Santa Margarita to Sterling (Colorado) | 927.18 mi (1,492.15 km) |
| Rancho Santa Margarita to Sterling (Illinois) | 1,617.39 mi (2,602.94 km) |
| Rancho Santa Margarita to Sterling (Virginia) | 2,249.72 mi (3,620.57 km) |
| Rancho Santa Margarita to Sterling Heights (Michigan) | 1,962.74 mi (3,158.73 km) |
| Rancho Santa Margarita to Steubenville (Ohio) | 2,075.28 mi (3,339.85 km) |
| Rancho Santa Margarita to Stevens Point (Wisconsin) | 1,670.65 mi (2,688.65 km) |
| Rancho Santa Margarita to Stevenson Ranch (California) | 77.15 mi (124.16 km) |
| Rancho Santa Margarita to Stillwater (Minnesota) | 1,531.66 mi (2,464.97 km) |
| Rancho Santa Margarita to Stillwater (Oklahoma) | 1,173.83 mi (1,889.09 km) |
| Rancho Santa Margarita to Stockbridge (Georgia) | 1,912.38 mi (3,077.67 km) |
| Rancho Santa Margarita to Stockton (California) | 365.14 mi (587.63 km) |
| Rancho Santa Margarita to Stone Ridge (Virginia) | 2,241.93 mi (3,608.03 km) |
| Rancho Santa Margarita to Stonecrest (Georgia) | 1,915.81 mi (3,083.19 km) |
| Rancho Santa Margarita to Stony Brook (New York) | 2,469.03 mi (3,973.52 km) |
