| Rancho Santa Margarita to St. Simons (Georgia) | 2,108.56 mi (3,393.40 km) |
| Rancho Santa Margarita to Stafford (Texas) | 1,322.70 mi (2,128.69 km) |
| Rancho Santa Margarita to Stallings (North Carolina) | 2,097.03 mi (3,374.85 km) |
| Rancho Santa Margarita to Stamford (Connecticut) | 2,445.97 mi (3,936.41 km) |
| Rancho Santa Margarita to Stanford (California) | 366.90 mi (590.47 km) |
| Rancho Santa Margarita to Stanton (California) | 25.50 mi (41.03 km) |
| Rancho Santa Margarita to Star (Idaho) | 698.37 mi (1,123.91 km) |
| Rancho Santa Margarita to Starkville (Mississippi) | 1,651.31 mi (2,657.52 km) |
| Rancho Santa Margarita to State College (Pennsylvania) | 2,222.20 mi (3,576.28 km) |
| Rancho Santa Margarita to Staten Island (New York) | 2,416.70 mi (3,889.31 km) |
| Rancho Santa Margarita to Statesboro (Georgia) | 2,066.29 mi (3,325.38 km) |
| Rancho Santa Margarita to Statesville (North Carolina) | 2,079.23 mi (3,346.19 km) |
| Rancho Santa Margarita to Staunton (Virginia) | 2,163.91 mi (3,482.48 km) |
| Rancho Santa Margarita to Steamboat Springs (Colorado) | 758.41 mi (1,220.54 km) |
| Rancho Santa Margarita to Steiner Ranch (Texas) | 1,174.43 mi (1,890.06 km) |
