| Rancho Santa Margarita to St. George (Utah) | 328.62 mi (528.86 km) |
| Rancho Santa Margarita to St. Helens (Oregon) | 888.49 mi (1,429.89 km) |
| Rancho Santa Margarita to St. James (New York) | 2,467.87 mi (3,971.65 km) |
| Rancho Santa Margarita to St. John (Indiana) | 1,726.49 mi (2,778.51 km) |
| Rancho Santa Margarita to St. Joseph (Missouri) | 1,326.67 mi (2,135.07 km) |
| Rancho Santa Margarita to St. Louis (Missouri) | 1,558.86 mi (2,508.74 km) |
| Rancho Santa Margarita to St. Louis Park (Minnesota) | 1,504.72 mi (2,421.61 km) |
| Rancho Santa Margarita to St. Marys (Georgia) | 2,105.26 mi (3,388.08 km) |
| Rancho Santa Margarita to St. Marys (Pennsylvania) | 2,187.46 mi (3,520.37 km) |
| Rancho Santa Margarita to St. Matthews (Kentucky) | 1,806.85 mi (2,907.85 km) |
| Rancho Santa Margarita to St. Michael (Minnesota) | 1,497.01 mi (2,409.20 km) |
| Rancho Santa Margarita to St. Paul (Minnesota) | 1,516.46 mi (2,440.51 km) |
| Rancho Santa Margarita to St. Peter (Minnesota) | 1,461.00 mi (2,351.25 km) |
| Rancho Santa Margarita to St. Peters (Missouri) | 1,540.28 mi (2,478.84 km) |
| Rancho Santa Margarita to St. Petersburg (Florida) | 2,103.70 mi (3,385.58 km) |
