| Rancho Santa Margarita to Spout Springs (North Carolina) | 2,186.34 mi (3,518.58 km) |
| Rancho Santa Margarita to Spring (Texas) | 1,324.32 mi (2,131.29 km) |
| Rancho Santa Margarita to Spring Creek (Nevada) | 503.62 mi (810.49 km) |
| Rancho Santa Margarita to Spring Hill (Florida) | 2,095.84 mi (3,372.92 km) |
| Rancho Santa Margarita to Spring Hill (Tennessee) | 1,742.44 mi (2,804.18 km) |
| Rancho Santa Margarita to Spring Lake (North Carolina) | 2,189.30 mi (3,523.33 km) |
| Rancho Santa Margarita to Spring Valley (California) | 71.85 mi (115.63 km) |
| Rancho Santa Margarita to Spring Valley (Nevada) | 215.61 mi (346.99 km) |
| Rancho Santa Margarita to Spring Valley (New York) | 2,420.44 mi (3,895.33 km) |
| Rancho Santa Margarita to Springboro (Ohio) | 1,884.14 mi (3,032.24 km) |
| Rancho Santa Margarita to Springdale (Arkansas) | 1,336.58 mi (2,151.01 km) |
| Rancho Santa Margarita to Springdale (New Jersey) | 2,375.92 mi (3,823.67 km) |
| Rancho Santa Margarita to Springdale (Ohio) | 1,870.69 mi (3,010.58 km) |
| Rancho Santa Margarita to Springfield (Illinois) | 1,597.82 mi (2,571.45 km) |
| Rancho Santa Margarita to Springfield (Massachusetts) | 2,496.17 mi (4,017.20 km) |
